I've been researching and building this for a long time. I am really happy with it at this point.
Signal Chain:
Line6 M5 - octavers, EQ, or synth presets
Source Audio OFD - OD's, fuzzes, and EQ, volume adjustments, LPF
Source Audio Manta - Filters, fuzz, phaser, and EQ tweaks
The RP-1 (the controller/board on the left) is a guitar multi effects but the audio does not run through it. It is used as a MIDI controller. I have 10 1 click presets on it (more 'banks available, just havent programmed them yet.) Every preset makes each effect go to where I need it. For example, my always on OD sets the M5 to octaver and OFF, the OFD to light OD, and the Manta OFF. I can click on the M5 as needed. My synthy sound on patch 7/8 turns the M5 to the synth patches, the OFD for volume control since the M5 lacks this on same presets, and the Manta OFF. It's pretty awesome and it wasn't hard at all to set up.
I am currently working on a video run through off all my current presets. I'll post it once it's all done.
Future plans, add a dedicated Source audio EQ, expression pedal and/or hot hand, always on the hunt for synthy stuff and fuzz.